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Antioxidative potential of metformin: Possible protective mechanism against generating OH radicals

Huibin Guo, Ning Wang, Xiang Li

《环境科学与工程前沿（英文）》 2021年 第15卷 第2期 doi: 10.1007/s11783-020-1313-2

摘要： Abstract • Metformin consumes O2−• and OH• induced by PM are proposed. • OH• dominated the oxidation of metformin compared with O2−• • Metformin can prevent the harm of ROS induced by PM to human health. • Antioxidative potential of metformin was first proposed to provide measures. Exposure to particulate matter (PM) can lead to the excessive accumulation of reactive oxygen species (ROS), which causes oxidative stress and endangers human health. In this study, the effects of metformin on PM-induced radicals were investigated, and the antioxidation reaction mechanism of metformin was analyzed by the density functional theory (DFT) method. The corresponding results revealed that the consumption rate of dithiothreitol (DTT) increased as the metformin concentration (0–40 mmol/L) increased under exposure to PM active components. Moreover, the OH radical content decreased as the metformin concentration increased. This result may be related to the consumption of PM-induced OH radicals by metformin, which promotes the DTT consumption rate. Additionally, because the initiation reaction has a high barrier, the oxidation reaction rate between metformin and •O2− is not very fast, although various catalysts may be present in the human environment. Importantly, we found that the barrier of metformin induced by OH radicals is only 9.6 kcal/mol while the barrier of metformin induced by oxygen is 57.9 kcal/mol, which shows that the rate of the •OH-initiated oxidative reaction of metformin is much faster and that this reaction path occurs more easily. By sample analysis, the mean OH radical generation was 55 nmol/min/g (ranging from 5 to 105 nmol/min/g) on haze days and 30 nmol/min/g (ranging from 10 to 50 nmol/min/g) on non-haze days. Moreover, OH radical generation was higher on haze days than on neighboring non-haze days. Taken together, all data suggest that metformin could consume the PM-induced radicals, such as OH radicals and •O2−, thereby providing health protection.

关键词： Antioxidative potential     Metformin     Mechanism     OH radical     Health protection.    

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“Heavenly Road”: The Qinghai–Tibet Railway

Yongfu SUN

《工程管理前沿（英文）》 2020年 第7卷 第2期   页码 304-307 doi: 10.1007/s42524-019-0079-3

摘要： Xiaobo WANG. [J]. Front. Eng, 2019, 6(1): 131-137.Peter REDFERN, Hua ZHONG. [J]. Front. Eng, 2017, 4(2): 193-200.Qixiang FAN. [J]. Front. Eng, 2017, 4(2): 231-237.Ming-zhou Liu,Cong-hu Liu,Mao-gen Ge,Yuan Zhang,Qing-hua Zhu. [J]. Front. Eng, 2016, 3(2): 144-146.Yu Zhao,Sheng-quan Wang,Ke-chao Zhu. [J]. Front. Eng, 2015, 2(1): 35-38.Ru-gui Chen,Jia-meng Chen. [J]. Front. Eng, 2014, 1(1): 52-61.An Wang. [J]. Front. Eng, 2014, 1(1): 13-17.

关键词： permafrost protection     sustainable development     health guarantee system    

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Implement and Innovate Environmental Protection Measures, Promote Green Protection of Cultural Relics

Fu-qing Liang,Yong-ping Sun

《工程管理前沿（英文）》 2014年 第1卷 第4期   页码 330-335 doi: 10.15302/J-FEM-2014055

摘要： The subject is implementing and innovating environmental protection measures, and promoting green protection of cultural relics in the Three Gorges area. This thesis states its significance and effect in the beginning, and then summarizes seven pieces of main practice, includes five pieces of main effect. In the end, this thesis produces some relevant conclusions and suggestions about the subject.

关键词： environmental science     the Three Gorges cultural relics     innovate environmental protection measures     green protection    

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新时期国家环境保护战略研究

郝吉明,万本太,侯立安,王金南,蒋洪强,许嘉钰

《中国工程科学》 2015年 第17卷 第8期   页码 30-38

摘要：

为探索在生态文明建设理念指导下，如何总体上把握生态保护和建设的发展战略，采取多学科、宽领域、全方位、深层次、开放式的战略研究方法进行了深入研究分析，提出了我国生态保护和建设的基本思路、基本原则、战略目标、战略布局、主要任务、战略重点以及政策建议，以期对我国生态保护和建设起到推动作用。

关键词： 水环境；大气环境；土壤环境；固体废物污染；海洋环境；农村环境；环境风险与健康；国际环境保护    

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Primary health care for all by 2020: The systematic reform of the medical and health system in China

《医学前沿（英文）》 2010年 第4卷 第1期   页码 3-7 doi: 10.1007/s11684-010-0024-7

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The next step of community health construction: Training general practitioners and implementing health

Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,

《医学前沿（英文）》 2010年 第4卷 第2期   页码 134-138 doi: 10.1007/s11684-010-0041-6

摘要： This article discusses the concept of health management and stresses that community health management should be the starting point of community health service, necessitating a paradigm shift from observing the treatment-oriented medical model to observing the prevention-and-health management-based medical model. Community health construction has entered a new phase, one which highlights the need to train general practitioners in practice-based life cycle health management. In addition, general practitioners should assume the mission of implementing community health management.

关键词： community health     general practitioners     health management    

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Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

《环境科学与工程前沿（英文）》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1475-6

摘要：

• The concentrations of 13 heavy metals in Taihu Lake were analyzed.

关键词： Heavy metals     Human health ambient water quality criteria     Taihu Lake     Health risk assessment     Contribution rate    

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CROP PROTECTION OPENS UP NEW ERA OF CONSERVATION AND UTILIZATION OF GREEN OPTIONS

《农业科学与工程前沿（英文）》 2022年 第9卷 第1期   页码 1-3 doi: 10.15302/J-FASE-2021431

摘要：

China is the largest agricultural producer in the world. Reducing yield losses caused by pests is an important issue and major challenge for China, especially when confronting global climate change, biological invasions and declining agricultural biodiversity of recent decades. Wang et al. (this issue) summarized the impacts of changing climate on two staple crops in China, wheat and rice (https://doi.org/FASE-2021432). They reviewed the impacts of climate change on crops, crop pests and crop diseases. Basically, increased temperature would reduce crop yields and increase pest damage. Biological invasions have become a serious threat to the agriculture worldwide. Developing approaches for monitoring and controlling invasive pests, such as fall armyworm, has been recognized as high priority for China. The excessive use of highly toxic pesticides has caused considerable damage to the environment and biodiversity, which is also one of the many contributors to the increasing outbreaks of pests and diseases. In addition, understanding interaction between crop pests and plant diseases is another critical challenge for agriculture. About 80% plant viruses can be transmitted by crop pest vectors such as aphids, whiteflies and other hemipteran pests. Therefore, to solve the problem of crop pests and diseases, suitable green crop protection methods have been identified as a key components of sustainable development. This special issue of Frontiers of Agricultural Science and Engineering outlines potential conservation and utilization of green options for crop protection.

To prevent outbreaks of crop pests, an advanced monitoring and early warning system could be the first step in crop protection. The use of science and technology in monitoring and early warning of major crop pests provides better pest management and acts as a fundamental part of an integrated plant protection strategy to achieve the goal of sustainable development of agriculture. Wu et al. (this issue) summarized the fundamental information on pest monitoring and early warning in China by documenting the history of research and application, Chinese laws and regulations related to plant protection, and the National Monitoring and Early Warning System, with the purpose of presenting the Chinese model as an example of how to promote regional management of crop pests, especially cross border pests such as fall armyworm and locust, by international cooperation across pest-impacted countries (https://doi.org/10.15302/J-FASE-2021411). They provide an overview of long-term Chinese efforts in the fight against major pests and to present the country’s experience in crop pest monitoring and early warning technology to the world.

Field management is a traditional conservation agriculture technique on plant protection such as no-till cropping, crop rotation, intercropping and cover cropping. Shi et al. (this issue) found that soil solarization is an environmental-friendly promising strategy that achieved complete mortality to the larvae of Bradysia cellarum (https://doi.org/10.15302/J-FASE-2021402). Crop rotation, intercropping and cover cropping of different crops or plants could help to reduce the outbreak of crop pests and diseases. Wang et al. (this issue) summarized the interactions and trade-offs between plants and entomophagous arthropods, and discussed a landscape management method by sowing flowering plants in agricultural fields (https://doi.org/10.15302/J-FASE-2021427). However, such methods are limited when crop pests have already become well established in crop fields.

Pesticides are widely used in the crop protection. The ideal pesticide should have high effectiveness in the control crop pests but low toxicity to non-target organisms. In this case, biopesticides including biochemical pesticides, microbial pesticides and plant-incorporated protectants are considered to be potential ideal pesticides for crop protection. Biochemical pesticides are the naturally occurring substances, they are derived from animals, plants and microorganisms. Microbial pesticides mainly rely on bacteria, fungi, virus or protozoans as the active agent. They are environment-friendly biopesticides with high effectiveness and species-specificity, and have been commercialized worldwide, for example, Bacillus thuringiensis. Plant-incorporated protectants are products that are genetically incorporated into plant tissues including chemicals, proteins or dsRNA for pest control or anti-microbial activity. Qu et al. (this issue) systematically introduced bioinsecticides for pest control and discussed current constraints that prevent bioinsecticides from being widely used and proposed the future research directions in this issue (https://doi.org/10.15302/J-FASE-2021404). Xu et al. (this issue) optimized synthesis process of an anti-plant-virus candidate drug NK0238, and evaluated the antivirus activity and environmental safety of this product (https://doi.org/10.15302/J-FASE-2021390). Zhu et al. (this issue) investigated a new family of natural cyclic lipodepsipeptides with potent activity against Gram-positive bacteria. By genetic manipulation of accessory genes in the WAP biosynthetic gene cluster, new WAP-8294As were produced in Lysobacter, which confirmed the possibility to expand the spectrum of the biocontrol compounds (https://doi.org/10.15302/J-FASE-2021410). In addition, structural biology studies on action targets provides important insights on molecular functions. Using a structure-based drug design strategy, Zheng et al. (this issue) prepared a battery of novel triketone-quinoxaline compounds, which could be potentially applied to design new herbicides targeting p-hydroxyphenylpyruvate dioxygenase (https://doi.org/10.15302/J-FASE-2021401).

With the development and application of new biotechnology in agriculture, opportunities for crop protection are great becoming more abundant, opening new approaches, such as genetic engineering, to improve the plant resistance against crop pests and diseases. It is now feasible to control pests by directly targeting genes that are essential for the development and survival of insects and pathogenic microorganisms, for example, the sterile insect technique based on gene-drive and RNA interference using dsRNA. In addition, it has been confirmed that some gene families are effective targets that indirectly contribute to crop pests and diseases protection by targeting the plant biochemical synthesis or virus transmitting pathways. In this case, identifying new genes associated with the interaction between crops, insects, microorganisms should be a key focus, both now and in the future. Huang et al. (this issue) summarized the recent research on the interaction between plant viruses and insect vectors, and discussed the potential control strategies to prevent the transmission of insect-vectored plant viruses using RNAi technology, gene editing technology and gene-driven technology (https://doi.org/10.15302/J-FASE-2021389).

We anticipate that the ideas and approaches highlighted in this issue will help broaden reader’s perspectives on every increasing prospect for a new era of sustainable and environment-friendly agricultural pest management.

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Bioengineering protection mechanism of city rock slope and its laboratory test

Desong JIANG, Minghua ZHAO, Chong JIANG,

《结构与土木工程前沿（英文）》 2009年 第3卷 第4期   页码 414-421 doi: 10.1007/s11709-009-0055-9

摘要： Based on the features of rock slope bioengineering protection, the ecology protection mechanism of the urban rock slope was discussed with the mechanics effect of plants and rock slope, and the reinforcement action mechanism of rock slope by plant root system was analyzed as well. Then, the corresponding mechanical model was proposed, from which the formula to calculate the increased shearing strength of the root system-earth compound body was derived. Moreover, the side slope rainfall interception, the runoff lagging, the soil antiseepage, and the soil layer consolidating effect were studied, respectively. Furthermore, the indoor model experiment of urban crag rock slope ecology protection was designed and completed, in which various grasses to plant in slope with different angles, solid earth forms, and the different strengthening earth mechanism were studied. Finally, the present method was applied in an engineering project, from which the antiwashing behavior of three kind of grasses (i.e., the Bahiagrass, the tall fescue, and the Bermudagrass) planted in the slope with an angle of 38°, 48°, and 58°, respectively, and different strengthening structures (i.e., the diamond wire netting, the geocell and the three-dimensional network) were obtained. The application results also show that the effect of geocell structure is the best one followed by the three-dimensional net and the diamond wire net. The antiwashing capability per unit area has a critical slope angle of about 25°. The reinforcing effect of Bermudagrass is better than the Bahiagrass and tall fescue.

关键词： indoor     engineering project     protection mechanism     different     runoff lagging    

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Percolation-based health management of complex traffic systems

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 557-571 doi: 10.1007/s42524-021-0174-0

摘要： System health management, which aims to ensure the safe and efficient operation of systems by reducing uncertain risks and cascading failures during their lifetime, is proposed for complex transportation systems and other critical infrastructures, especially under the background of the New Infrastructure Projects launched in China. Previous studies proposed numerous approaches to evaluate or improve traffic reliability or efficiency. Nevertheless, most existing studies neglected the core failure mechanism (i.e., spatio–temporal propagation of traffic congestion). In this article, we review existing studies on traffic reliability management and propose a health management framework covering the entire traffic congestion lifetime, from emergence, evolution to dissipation, based on the study of core failure modes with percolation theory. Aiming to be “reliable, invulnerable, resilient, potential, and active”, our proposed traffic health management framework includes modeling, evaluation, diagnosis, and improvement. Our proposed framework may shed light on traffic management for megacities and urban agglomerations around the world. This new approach may offer innovative insights for systems science and engineering in future intelligent infrastructure management.

关键词： traffic health     health management     critical infrastructure     systems science and engineering    

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Structural health monitoring with fiber optic sensors

F. ANSARI

《机械工程前沿（英文）》 2009年 第4卷 第2期   页码 103-110 doi: 10.1007/s11465-009-0032-y

摘要： Optical fiber sensors have been successfully implemented in aeronautics, mechanical systems, and medical applications. Civil structures pose further challenges in monitoring mainly due to their large dimensions, diversity and heterogeneity of materials involved, and hostile construction environment. This article provides a summary of basic principles pertaining to practical health monitoring of civil engineering structures with optical fiber sensors. The issues discussed include basic sensor principles, strain transfer mechanism, sensor packaging, sensor placement in construction environment, and reliability and survivability of the sensors.

关键词： Bridges     structural health monitoring     smart skins     cracks     strains     displacements     fiber optic sensors     FBG     structures    

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Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1376-0

摘要：

•Annual mean PM2.5 in Shijiazhuang were 87, 95, and 82 µg/m3 in 2015–2017.

关键词： PM2.5     Health effects     Integrated exposure-response model     Shijiazhuang    

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Multimedia distribution and health risk assessment of typical organic pollutants in a retired industrial

《环境科学与工程前沿（英文）》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1742-9

摘要：

● A fine portrayal of organic pollutants in a retired industrial park is provided.

关键词： Organic pollutants     Retired industrial park     Spatial correlation     Health risk assessment    

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

null

《医学前沿（英文）》 2012年 第6卷 第1期   页码 1-7 doi: 10.1007/s11684-012-0173-y

摘要：

The patterns of modern science and changes in the medical model can result in the transformation of the current state of individualized and health medicines into being the primary trend in medical development. Chinese and Western medical systems are dissimilar in terms of value orientations, thinking style, and research directions because of their different historical and cultural backgrounds. Individualized treatment in modern medicine is mainly established based on individual genome information and the differences in mononucleotide polymorphi-sms. However, such treatment method is expensive, creates an uncertain genetic marker, and leads to different result interpretations, among other problems. The Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicine and individual treatment and provides the corresponding methods. The Chinese constitutional theory divides the constitution of the Chinese population into nine categories based on established classification criteria. It promotes the study of the relationship of each constitution to diseases and Chinese medicine preparation toward adjusting the constitution and preventing diseases. The theory also provides methods and tools for individualized treatment. Constitution identification shows the direction and provides the core technology for the evaluation of the health status. By combining the developments in modern biotechnology, new diagnostic techniques and treatment models of constitution-differentiation, disease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicine treatment and health medicine for the international medical community.

关键词： individualized medicine     health medicine     constitutional theory in Chinese medicine    

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Effective interventions on health effects of Chinese rural elderly under heat exposure

《环境科学与工程前沿（英文）》 2022年 第16卷 第5期 doi: 10.1007/s11783-022-1545-4

摘要：

● Education and subsidy were effective interventions during short-term heat exposure.

关键词： High temperature     Health effect     Comprehensive evaluation     Intervention     Rural elderly    

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标题 作者 时间 类型 操作

Antioxidative potential of metformin: Possible protective mechanism against generating OH radicals

Huibin Guo, Ning Wang, Xiang Li

期刊论文

“Heavenly Road”: The Qinghai–Tibet Railway

Yongfu SUN

期刊论文

Implement and Innovate Environmental Protection Measures, Promote Green Protection of Cultural Relics

Fu-qing Liang,Yong-ping Sun

期刊论文

新时期国家环境保护战略研究

郝吉明,万本太,侯立安,王金南,蒋洪强,许嘉钰

期刊论文

Primary health care for all by 2020: The systematic reform of the medical and health system in China

期刊论文

The next step of community health construction: Training general practitioners and implementing health

Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,

期刊论文

Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

期刊论文

CROP PROTECTION OPENS UP NEW ERA OF CONSERVATION AND UTILIZATION OF GREEN OPTIONS

期刊论文

Bioengineering protection mechanism of city rock slope and its laboratory test

Desong JIANG, Minghua ZHAO, Chong JIANG,

期刊论文

Percolation-based health management of complex traffic systems

期刊论文

Structural health monitoring with fiber optic sensors

F. ANSARI

期刊论文

Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

期刊论文

Multimedia distribution and health risk assessment of typical organic pollutants in a retired industrial

期刊论文

Individualized medicine, health medicine, and constitutional theory in Chinese medicine

null

期刊论文

Effective interventions on health effects of Chinese rural elderly under heat exposure

期刊论文